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Date: Sun, 6 Feb 2022 08:18:06 -0800
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From: "Jennifer - FHA Rate Guide" <Jennifer-FHARateGuide@programguide.biz>
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Subject:    Big Surprise Inside

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Big Surprise Inside

 


http://www.programguide.biz/l/lc10AF6853MO78HX/3346DN5756FK7078N117R48144354IX1566796073
A literature review of 2014 found that non-coeliac gluten sensitivity diagnosis can be reached only by excluding celiac disease (CD) and wheat allergy.[65] Persons suspected of having celiac disease may undergo serological testing for IgA anti-tissue transglutaminase antibodies (abbreviated anti-tTG antibodies or anti-TG2 antibodies) and anti-endomysial antibodies (abbreviated EMA) provided the IgA-level is high, and if IgA is low, testing for certain IgG antibodies; in case of positive serological indication, a duodenal biopsy may confirm active celiac disease.[66] Eliminating the possibility of CD can generally also be done by adding HLA-DQ typing. The absence of HLA-DQ2 and HLA-DQ8 has a very high negative predictive value for CD,[2][67] and the predictive value can be further enhanced by including HLA-DQ7.5 (HLA-DQ2 and HLA-DQ8 are found in coeliac disease 98% of the time in Caucasians, HLA-DQ7.5 present in the remaining 1.6% and only 0.4% of Caucasians are missed with the combination of these three).[citation needed] Without serological or HLA-DQ2/8 positivity, celiac disease is likely not present. HLA-DQ typing has a practical advantage in that it is the only diagnostic test that allows to exclude CD when a person is already on a gluten-free diet; however, as not only celiacs are HLA-DQ2/HLA-DQ8 positive, this method has a higher false positive rate than anti-TG2 and EMA antibody testing. A four-of-five rule was proposed 2010 for confirming celiac disease, with the disease confirmed if at least four of the following five criteria are satisfied:[2][68] typical symptoms of celiac disease; positivity of serum celiac disease immunoglobulin, A class autoantibodies at high titer;



























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=09<title>Newsletter</title>
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<p style=3D"color:#FFFFFF;">A literature review of 2014 found that non-coel=
iac gluten sensitivity diagnosis can be reached only by excluding celiac di=
sease (CD) and wheat allergy.[65]

Persons suspected of having celiac disease may undergo serological testing =
for IgA anti-tissue transglutaminase antibodies (abbreviated anti-tTG antib=
odies or anti-TG2 antibodies) and anti-endomysial antibodies (abbreviated E=
MA) provided the IgA-level is high, and if IgA is low, testing for certain =
IgG antibodies; in case of positive serological indication, a duodenal biop=
sy may confirm active celiac disease.[66]

Eliminating the possibility of CD can generally also be done by adding HLA-=
DQ typing. The absence of HLA-DQ2 and HLA-DQ8 has a very high negative pred=
ictive value for CD,[2][67] and the predictive value can be further enhance=
d by including HLA-DQ7.5 (HLA-DQ2 and HLA-DQ8 are found in coeliac disease =
98% of the time in Caucasians, HLA-DQ7.5 present in the remaining 1.6% and =
only 0.4% of Caucasians are missed with the combination of these three).[ci=
tation needed] Without serological or HLA-DQ2/8 positivity, celiac disease =
is likely not present. HLA-DQ typing has a practical advantage in that it i=
s the only diagnostic test that allows to exclude CD when a person is alrea=
dy on a gluten-free diet; however, as not only celiacs are HLA-DQ2/HLA-DQ8 =
positive, this method has a higher false positive rate than anti-TG2 and EM=
A antibody testing.

A four-of-five rule was proposed 2010 for confirming celiac disease, with t=
he disease confirmed if at least four of the following five criteria are sa=
tisfied:[2][68]

typical symptoms of celiac disease;
positivity of serum celiac disease immunoglobulin, A class autoantibodies a=
t high titer;</p>
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